Effects of IκBα and its mutants on NF-κB and p53 signaling pathways

SnapShot: NF-κB Signaling Pathways

Activation of Wnt signaling reduces high-glucose mediated damages on skin fibroblast cells

Objective(s): High-glucose (HG) stress, a mimic of diabetes mellitus (DM) in culture cells, alters expression of a large number of genes including Wnt and NF-κB signaling-related genes; however, the role of Wnt signaling during HG-mediated fibroblast damage and the relationship between Wnt and NF-κB signaling have not been understood. In this study, we aimed to investigate the ffects of Wnt sig...

Structure of an IκBα/NF-κB Complex

Each of the IkB proteins contains six or more 33The inhibitory protein, IkBa, sequesters the transcripresidue-long ankyrin repeats, named for their homology tion factor, NF-kB, as an inactive complex in the cytoto repeats in the erythrocyte protein ankyrin (reviewed plasm. The structure of the IkBa ankyrin repeat domain, in Bork, 1993). Ankyrin, which has 24 such repeats, links bound to a parti...

the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance

this study compared the different effects of form-focused guided planning vs. meaning-focused guided planning on iranian pre-intermediate students’ task performance. the study lasted for three weeks and concentrated on eight english structures. forty five pre-intermediate iranian students were randomly assigned to three groups of guided planning focus-on-form group (gpfg), guided planning focus...

simultaneous analysis of wnt and nf-κb signaling pathways in doxorubicin sensitive and methotrexate resistant plc/ prf/5 cells

background: multi-drug resistance (mdr) is a controversial issue in traditional chemotherapy of aggressive cancers, including hepatocellular carcinoma. the major cause of mdr is suggested to be the aberrant activation of the main signaling pathways such as wnt and nuclear factor kappa-light-chain-enhancer of activated b cells (nf- κb) which have key roles in the maintenance of cancer stem cells...